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| Aliases | Conical cornea; KCN; Acquired conus of cornea; Bulging cornea |
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| Inheritance | - |
| Age of onset | Adolescence |
| Description | Keratoconus is a bilateral and asymmetric disease which results in progressive thinning and steeping of the cornea leading to irregular astigmatism and decreased visual acuity. Traditionally, the condition has been described as a noninflammatory disease; however, more recently it has been associated with ocular inflammation. Keratoconus normally develops in the second and third decades of life and progresses until the fourth decade. The condition affects all ethnicities and both sexes. The prevalence and incidence rates of keratoconus have been estimated to be between 0.2 and 4,790 per 100,000 persons and 1.5 and 25 cases per 100,000 persons/year, respectively, with highest rates typically occurring in 20- to 30-year-olds and Middle Eastern and Asian ethnicities. Progressive stromal thinning, rupture of the anterior limiting membrane, and subsequent ectasia of the central/paracentral cornea are the most commonly observed histopathological findings. A family history of keratoconus, eye rubbing, eczema, asthma, and allergy are risk factors for developing keratoconus. |
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| Symbol | Entrez ID | Official full name | Location | Also known as |
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| Symbol | Variation location | dbSNP | Condition | Clinical significance | RCV accession |
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| Transcriptomics | Single-cell | Spatial-map | Epigenomics | Proteomics | Metabolomics |
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