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| Aliases | Fuchs endothelial dystrophy; Fuchs dystrophy; Fuchs' endothelial dystrophy |
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| Inheritance | Autosomal dominant, Multigenic/multifactorial |
| Age of onset | Adults |
| Description | Fuchs endothelial corneal dystrophy (FECD) is an autosomal dominant genetic disorder characterized by the destruction of the structure and function of corneal endothelial cells. This condition is commonly observed in women aged 40-70 years. In individuals with FECD, the corneal endothelial cells produce abnormal basement membrane and fibrous collagen deposits known as guttae, which further damage the corneal endothelial cells. This damage results in the loss of endothelial barrier function and pump function, leading to corneal edema. The eventual loss of vision in FECD patients is related to the irregularities of the corneal endothelium and the loss of corneal transparency associated with corneal edema. |
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| Symbol | Entrez ID | Official full name | Location | Also known as |
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| Symbol | Variation location | dbSNP | Condition | Clinical significance | RCV accession |
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| Transcriptomics | Single-cell | Spatial-map | Epigenomics | Proteomics | Metabolomics |
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